Associate Professor of Pediatrics
Principal Investigator at the Shih Lab at Seattle Children’s Research Institute
Scholarly Focus: Dr. Shih initiated his independent research at the Medical University of South Carolina (2012‐2018) before moving to the city of Seattle. His research uses state‐of‐the‐art in vivo imaging methods to examine the basis of neurovascular function and dysfunction in models of stroke and small vessel disease. His recent studies have focused on microscopic ischemic lesions often observed in VCID (cerebral microinfarcts), and their enduring effects that may contribute to cognitive impairment. A second line of research examines microvascular pericytes and their role in maintaining vascular stability in the developing and adult brain. His research has been continually funded by the NIH (NINDS and NIA), and by Foundations such as the American Heart Association, Dana Foundation NeuroImaging Award, Alzheimer’s Association New Investigator Award, and Charleston Conference on Alzheimer’s Disease New Vision Award. More information can be found on his lab website: Theshihlab.com.
2017‐2022 Deciphering the Cerebral Microinfarct and its Role in Vascular Cognitive Impairment, R01 NS097775. Role: PI, Total Award: $1,964,790
2018‐2020 Cytoskeletal Dynamics of Brain Pericytes and Impact on Capillary Flow, R21 NS106138.
Role: PI, Total Award: $275,000
2019‐2021 The Effects of Amyloid Beta on Pericyte Remodeling and Brain Capillary Function In Vivo, R21 NS106138. Role: PI, Total Award: $275,000
2019‐2020 Deep In Vivo Two‐photon Imaging of White Matter Pericytes During Ischemia, Albert Trust Foundation. Role: Co‐PI, Total Award: $75,000